Two ATP - binding cassette transporters involved in ( S ) - 2 - aminoethyl - cysteine uptake in 1
نویسندگان
چکیده
Two ATP-binding cassette transporters involved in (S)-2-aminoethyl-cysteine uptake in 1 Thermus thermophilus 2 3 Running title: AEC transporters of T. thermophilus 4 5 Yuko Kanemaru, Fumihito Hasebe, Takeo Tomita, Tomohisa Kuzuyama, and 6 Makoto Nishiyama 7 8 Biotechnology Research Center, The University of Tokyo, Tokyo 113-8657, Japan 9 RIKEN SPring-8 Center, Hyogo 679-5148, Japan 10 11 Corresponding author: Makoto Nishiyama, Ph.D. 12 Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 13 Tokyo 113-8657, Japan 14 Fax: +81-3-5841-8030; Phone: +81-3-5840-3074 15 E-mail: [email protected] 16 17 *Those authors contributed equally 18 19 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00202-13 JB Accepts, published online ahead of print on 21 June 2013
منابع مشابه
The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance
Acute lymphoblastic leukemia (ALL) is one of the most prevalent hematologic malignancies in children. Although the cure rate of ALL has improved over the past decades, the most important reason for ALL treatment failure is multidrug resistance (MDR) phenomenon. The current study aims to explain the mechanisms involved in multidrug resistance of childhood ALL, and introduces ATP-binding cassette...
متن کاملATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients.
BACKGROUND A major issue in the treatment of acute myeloid leukemia is resistance to chemotherapeutic drugs. An increasing number of ATP-Binding-Cassette transporters have been demonstrated to cause resistance to cancer drugs. The aim of this study was to highlight the putative role of other ATP-Binding-Cassette transporters in primary chemoresistant acute myeloid leukemia. DESIGN AND METHODS...
متن کاملمکانیسم مقاومت دارویی در سرطان
Some varieties of human cancers become resistant, or, are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due largely to over-expression of the ATP binding cassette, (ABC), super-family of membrane transporters. In this regard, 170 kDa plasma membrane ATP-dependent pump, known as P-glycoprotein are the most important. Other members of multi-drug resista...
متن کاملThree different systems participate in L-cystine uptake in Bacillus subtilis.
The symporter YhcL and two ATP binding cassette transporters, YtmJKLMN and YckKJI, were shown to mediate L-cystine uptake in Bacillus subtilis. A triple DeltayhcL DeltaytmJKLMN DeltayckK mutant was unable to grow in the presence of L-cystine and to take up L-cystine. We propose that yhcL, ytmJKLMN, and yckKJI should be renamed tcyP, tcyJKLMN, and tcyABC, respectively. The L-cystine uptake by Yh...
متن کاملMutations at the Signature Sequence of CFTR Create a Cd2+-gated Chloride Channel
The canonical sequence LSGGQ, also known as the signature sequence, defines the adenosine triphosphate (ATP)-binding cassette transporter superfamily. Crystallographic studies reveal that the signature sequence, together with the Walker A and Walker B motifs, forms the ATP-binding pocket upon dimerization of the two nucleotide-binding domains (NBDs) in a head-to-tail configuration. The importan...
متن کامل